Urology news for Thursday, October 1, 2026

Top 5 in urology

PACE-A: SBRT and prostatectomy show similar long-term cancer control Phase 3 RCT · Urology Times · 2026-09-28
Long-term follow-up of the PACE-A randomized trial finds SBRT and radical prostatectomy provide comparable disease control for localized prostate cancer.
Why it matters: Adds mature phase 3 evidence supporting SBRT as an alternative to surgery for localized disease.
PACE-A trial: sexual function outcomes compared between prostatectomy and SBRT Phase 3 RCT · UroToday · 2026-09-30
Long-term sexual function results from the multicenter randomized PACE-A trial comparing radical prostatectomy versus SBRT for early localized prostate cancer, presented at ASTRO 2026.
Why it matters: Functional outcome data help counsel patients choosing between surgery and radiotherapy for localized disease.
Urine methylation assay shows high sensitivity for detecting and monitoring urothelial cancer Prospective · JAMA Netw Open · 2026-09-30
A multicenter prospective study of a urine-based AL021918.2/vimentin methylation assay in over 2,300 patients found sensitivities around 91% and specificities around 90% for urothelial carcinoma detection and surveillance.
Why it matters: Could offer a noninvasive alternative or adjunct to cystoscopy and cytology for bladder cancer detection and surveillance.
Small phase 2 trial: PSMA PET-guided salvage therapy without ADT feasible in oligorecurrence Phase 1-2 · JU Open Plus · 2026-10-01
In 20 men with PET-defined oligorecurrent prostate cancer after prostatectomy, metastasis-directed therapy without androgen deprivation produced a 50% PSA decline in 40% at 6 months, with 12-month ADT-free survival around 71%.
Why it matters: Suggests a subset of oligorecurrent patients may be able to defer ADT using MDT alone, though pathology at salvage lymph node dissection often showed more extensive disease than PET predicted.
Enzalutamide added to salvage radiotherapy tied to better PFS in high-risk BCR Retrospective · Urology Times · 2026-09-29
A study reports that adding enzalutamide to salvage radiotherapy is associated with improved progression-free survival in patients with high-risk biochemical recurrence after prostatectomy.
Why it matters: Suggests a potential treatment intensification strategy for high-risk BCR patients undergoing salvage radiation.

Prostate cancer news

FDA grants fast track to pre-biopsy 68Ga-PSMA-PET imaging program FDA action · Urology Times · 2026-09-30
FDA awarded fast track designation to a program evaluating 68Ga-PSMA-PET combined with MRI for use before prostate biopsy to aid cancer detection.
Why it matters: Pre-biopsy PSMA-PET could eventually help refine who needs biopsy, pending further trial data.
CMS grants transitional pass-through payment status to PSMA PET agent PYLARIFY TruVu FDA action · The Manila Times · 2026-09-30
Lantheus announced CMS granted transitional pass-through status for its PSMA PET imaging agent piflufolastat F 18 (PYLARIFY TruVu), affecting hospital outpatient reimbursement.
Why it matters: Pass-through status changes reimbursement pathways for a PSMA PET tracer used in prostate cancer staging and recurrence imaging.
Egypt approves darolutamide plus ADT alone (without chemotherapy) for prostate cancer Intl regulatory · Ahram Online · 2026-09-30
Egyptian Drug Authority approved an expanded indication for darolutamide combined with hormone therapy without chemotherapy for prostate cancer, per the manufacturer.
Why it matters: Signals continued international expansion of darolutamide indications beyond chemo-combination regimens.
Single-institution series finds de novo neuroendocrine prostate cancer outlives treatment-emergent form Retrospective · Clin Genitourin Cancer · 2026-09-29
Among 58 patients with neuroendocrine prostate cancer, overall survival was longer for de novo versus treatment-emergent disease (26.5 vs 10.9 months) and for mixed versus pure histology; maintenance immunotherapy after carboplatin/etoposide showed no survival benefit.
Why it matters: Provides real-world benchmarks for a rare, aggressive prostate cancer subtype and suggests maintenance IO after platinum chemo may not help.
Model suggests individualized, risk-adapted PSA surveillance schedules after prostatectomy Retrospective · Eur Urol Oncol · 2026-09-26
In a study of 11,552 post-prostatectomy patients, a risk-adapted follow-up schedule based on recurrence hazard suggested more intensive PSA testing early for adverse pathology patients (quarterly for 2 years) with de-intensification over time, while favorable-feature patients needed testing only every 9 months.
Why it matters: Offers a data-driven framework for tailoring PSA surveillance intensity by pathologic risk and comorbidity rather than one-size-fits-all schedules.
NADIR model validated in ARCHES trial predicts early PSA response and survival with enzalutamide Retrospective · Cancer · 2026-09-26
External validation of the NADIR model in 558 ARCHES trial patients showed good discrimination (AUC 0.80) for predicting early favorable PSA response to enzalutamide in mHSPC, and higher predicted probability was associated with lower mortality in landmark analysis.
Why it matters: A validated tool predicting early PSA response could help identify mHSPC patients likely to benefit from ARPI therapy and inform treatment intensification discussions.

Bladder cancer news

Preoperative kidney impairment loses prognostic significance after adjusting for cancer stage in cystectomy cohort Retrospective · Clin Genitourin Cancer · 2026-10-01
In 396 radical cystectomy patients, reduced eGFR was linked to worse recurrence-free and overall survival in age/sex-adjusted models, but this association was substantially attenuated after adjusting for pathologic stage and treatment factors.
Why it matters: Suggests preoperative renal function may be a marker of more advanced disease rather than an independent prognostic factor, relevant for risk counseling before cystectomy.
ctDNA testing after cystectomy rose steadily since Medicare coverage but remains uncommon Retrospective · Urol Oncol · 2026-09-30
Claims data from 1,995 US bladder cancer patients undergoing radical cystectomy show ctDNA testing utilization increased from 4 to 34 tests per 1,000 patient-months between 2022 and 2025, with only 17% ever tested; median cost was about $4,178 with minimal out-of-pocket cost.
Why it matters: Highlights the gap between guideline interest in ctDNA-guided surveillance and actual real-world adoption after cystectomy.
Only 22% of NMIBC trials include patient-reported outcomes as endpoints Retrospective · BJU Int · 2026-09-30
Review of 94 interventional NMIBC trials on ClinicalTrials.gov since 1994 found patient-reported outcomes were incorporated in just 22% of trials, more often as secondary than primary endpoints, and were more common in larger randomized trials.
Why it matters: Points to a gap in capturing the patient experience in NMIBC trial design, relevant for future trial planning and FDA guidance alignment.
FDA grants priority review to durvalumab plus enfortumab vedotin regimen in bladder cancer FDA action · AllSci · 2026-09-28
AstraZeneca's Imfinzi (durvalumab) combined with enfortumab vedotin received FDA priority review designation for a bladder cancer indication.
Why it matters: A priority review shortens the timeline toward potential approval of a new combination regimen for urothelial cancer.
Frailty does not modify robotic vs open cystectomy outcomes in older adults Retrospective · Urology · 2026-09-27
In a SEER-Medicare emulated trial of 1,750 patients aged 66-89 with bladder cancer, robotic-assisted radical cystectomy showed no significant difference from open surgery in perioperative morbidity or oncologic outcomes, regardless of baseline frailty.
Why it matters: Suggests frailty status alone should not drive the choice between robotic and open cystectomy approaches.
FDA grants priority review to VOLGA regimen in bladder cancer FDA action · Oncodaily · 2026-09-26
A company representative noted FDA priority review for a combination regimen (VOLGA) targeting a bladder cancer indication, according to a brief interview item.
Why it matters: Priority review timelines could bring a new perioperative or metastatic urothelial regimen to market sooner.
Reanalysis shows BCG-unresponsive CIS response rates are not comparable across trials Meta-analysis · BJU Int · 2026-09-26
A reanalysis of six registrational BCG-unresponsive CIS trials found that differences in retreatment policy and biopsy timing substantially alter reported 12-month complete response rates, with TAR-200 outperforming an adjusted reference standard once mandatory biopsy protocols were applied.
Why it matters: Cross-trial comparisons of BCG-unresponsive CIS agents should be interpreted cautiously given major methodological heterogeneity.
Priority review for perioperative durvalumab plus enfortumab vedotin in cisplatin-ineligible MIBC FDA priority review · Urology Times · 2026-09-25
Based on phase 3 VOLGA, where the regimen improved event-free and overall survival versus cystectomy with or without adjuvant therapy. FDA decision expected Q4 2026.
Why it matters: Would give cisplatin-ineligible patients a second perioperative immunotherapy-ADC option alongside EV-pembrolizumab.
One year of Inlexzo: how BCG-unresponsive NMIBC care has shifted Perspective · Urology Times · 2026-09-25
A look back at the first year of the gemcitabine intravesical system in practice, including patient selection and workflow changes.
Why it matters: Useful for programs building an intravesical device workflow.

Kidney cancer news

Delaying nephrectomy beyond 3 months linked to higher cancer death risk in pT1b-2 RCC Retrospective · BJU Int · 2026-09-30
In a SEER analysis of over 16,000 patients with pT1b-2N0M0 RCC, time to surgery beyond 3 months was associated with a 1.3-fold higher cancer-specific mortality, with a dose-response effect worsening beyond 6 months; the association was not seen in non-clear cell RCC.
Why it matters: Supports avoiding unnecessary surgical delay in localized RCC, particularly for clear cell histology.
Final KEYNOTE-427 data show PD-L1 and gene profile predict pembrolizumab response in RCC Phase 1-2 · Ann Oncol · 2026-09-30
Long-term follow-up of first-line pembrolizumab monotherapy in advanced RCC found T-cell inflamed gene expression and PD-L1 CPS positively associated with response, while baseline detectable ctDNA predicted shorter overall survival.
Why it matters: Biomarker data could eventually help select patients most likely to benefit from single-agent checkpoint therapy in RCC.
FDA expands Welireg label for additional kidney cancer indication FDA action · Zacks Investment Research · 2026-09-28
Merck's belzutifan (Welireg) received an expanded FDA label covering a new indication in kidney cancer.
Why it matters: Broader labeling may extend access to belzutifan for additional renal cell carcinoma patient populations.
Multicenter study finds 18% discordance between renal mass biopsy and final surgical pathology Retrospective · World J Urol · 2026-09-29
Among 1,301 patients from the UroCCR registry, renal mass biopsy showed an 18% overall discordance rate with surgical pathology (3.7% for malignancy, 8.4% for subtype, 5.7% non-diagnostic), with cystic tumors linked to higher discordance and greater tumor complexity linked to lower discordance.
Why it matters: Quantifies real-world limitations of renal mass biopsy that should inform counseling before active surveillance or ablation decisions.
Meta-analysis: PFS and response rate weakly predict overall survival in mRCC trials Meta-analysis · UroToday · 2026-09-28
A systematic review and meta-analysis found that progression-free survival and objective response rate are weak surrogates for overall survival across metastatic renal cell carcinoma trials.
Why it matters: Reinforces caution when using surrogate endpoints alone to judge treatment benefit in RCC trials.
Young-onset RCC shows higher survival and more germline mutations than older-onset disease Retrospective · Clin Genitourin Cancer · 2026-09-29
In a retrospective cohort of 812 nephrectomy patients, those aged 46 or younger with RCC had higher 5-year overall survival (92.4% vs 80.9%) and more frequent germline alterations in FANCI, POLD1, PTCH1, and RINT1 versus older patients.
Why it matters: Suggests germline testing may be worth considering in younger RCC patients and that age at onset carries prognostic information.
FDA approves belzutifan-lenvatinib for ccRCC after PD-1/PD-L1 therapy FDA approval · Renal & Urology News · 2026-09-28
The FDA approved the combination of belzutifan and lenvatinib for advanced clear cell renal cell carcinoma following prior immunotherapy, based on trial data supporting the regimen in this setting.
Why it matters: Adds another approved option for RCC patients who progress after checkpoint inhibitor therapy.
FDA approves belzutifan plus lenvatinib for advanced clear cell RCC FDA approval · FDA · 2026-09-24
The FDA approved the combination of belzutifan and lenvatinib for advanced renal cell carcinoma with a clear cell component.
Why it matters: Adds a new combination option for patients with advanced clear cell RCC.
PFS and response rate only weakly predict overall survival in metastatic RCC trials Meta-analysis · Cancer · 2026-09-26
A meta-analysis of 62 randomized trials in metastatic RCC found moderate correlations between progression-free survival, objective response rate, and overall survival, with surrogate threshold effects that were imprecise, especially by histology subgroup.
Why it matters: Suggests caution in relying on PFS or ORR alone when interpreting or designing RCC trials; OS remains the preferred endpoint.
Half of eligible RCC patients declined adjuvant pembrolizumab in UK real-world cohort Retrospective · Eur Urol Oncol · 2026-09-26
Among 129 medically fit ccRCC patients eligible for adjuvant pembrolizumab per KEYNOTE-564 criteria at a UK renal cancer network, 50% declined therapy after counseling, with treated patients younger and having higher-risk features than those who chose surveillance.
Why it matters: Highlights a substantial gap between trial eligibility and real-world uptake of adjuvant immunotherapy for high-risk renal cell carcinoma.

Upper tract urothelial carcinoma news

CT urography and cytology miss most recurrences during UTUC endoscopic surveillance Retrospective · BJU Int · 2026-09-30
In a two-center study of 133 patients undergoing kidney-sparing endoscopic treatment for UTUC, combined CT urography and cytology avoided about 69% of surveillance ureteroscopies but missed nearly 65% of recurrences, with cytology alone highly specific but poorly sensitive.
Why it matters: Suggests noninvasive imaging and cytology cannot safely replace ureteroscopy for UTUC surveillance despite reducing procedure burden.
Meta-analysis: ureteroscopic biopsy forceps yield ~85% diagnostic rate in UTUC, no device superior Meta-analysis · J Endourol · 2026-09-29
Pooling 19 studies and over 1,700 biopsies, flexible ureteroscopy forceps achieved 84.6% diagnostic yield and 78.8% grade concordance in upper tract urothelial carcinoma, with over half of apparently non-muscle-invasive tumors upstaged at nephroureterectomy, and no forceps design outperforming others.
Why it matters: Reinforces that ureteroscopic biopsy alone should not be relied upon to exclude muscle-invasive UTUC when planning kidney-sparing therapy.

Testicular cancer news

EAU panel recommends centralized care to improve testicular cancer outcomes Guideline · UroToday · 2026-09-25
A European Association of Urology guidelines panel report argues that treatment at higher-volume centers is associated with better outcomes for testicular cancer patients, supporting centralization of care.
Why it matters: Referral pathways and case volume may influence outcomes in a highly curable cancer where errors have long-term consequences.

Endourology and stone disease news

Meta-analysis identifies risk factors for failed ureteroscope access before stone treatment Meta-analysis · J Endourol · 2026-09-30
Pooling 22 studies and nearly 8,750 procedures, primary ureteroscopic access failure occurred in 11% of cases; younger age, male sex, and proximal stone location increased risk, while thinner scopes and prior ipsilateral stone surgery were protective.
Why it matters: Helps identify patients who may benefit from prestenting or pretreatment to avoid failed access and staged procedures.
CT slice thickness biases stone-free rate assessment after RIRS Retrospective · World J Urol · 2026-09-28
In a retrospective cohort of 145 patients after retrograde intrarenal surgery, reconstructing CT images at 5-mm versus 1-mm slice thickness shifted 24% of patients to a more favorable stone-free grade, with no downgrades.
Why it matters: Reported stone-free rates depend heavily on CT reconstruction protocol, complicating comparisons across studies and centers.
Holmium and thulium fiber lasers show equivalent stone-free rates in RCT for kidney stone dusting RCT · J Urol · 2026-09-26
A 5-center US randomized trial of 178 patients found no significant difference in stone-free rates (about 53% for each), procedure time, or complications between pulse-modulated Holmium:YAG and Thulium Fiber Laser during retrograde intrarenal surgery for stones up to 20 mm.
Why it matters: Provides high-level evidence that laser choice for retrograde intrarenal surgery can be based on surgeon or institutional preference rather than presumed superiority.
AUA updates guideline on medical management of kidney stones Guideline · Renal & Urology News · 2026-09-25
The American Urological Association has released an updated guideline covering medical management strategies for kidney stone disease, including prevention and pharmacologic approaches.
Why it matters: Guideline updates directly inform counseling and prescribing for stone formers in daily practice.
Antibiotic-augmented irrigation during PCNL cut infection rates in high-risk patients Retrospective · J Endourol · 2026-09-26
In a matched cohort of 100 high-infection-risk PCNL patients, intrarenal neomycin/polymyxin B irrigation reduced 30-day UTI (6% vs 34%), sepsis (0% vs 16%), and prolonged hospitalization compared with standard saline irrigation.
Why it matters: Suggests a simple intraoperative modification that could meaningfully reduce infectious complications in higher-risk stone surgery patients.
Meta-analysis quantifies ureteral perforation and avulsion risk during ureteroscopy Meta-analysis · Urolithiasis · 2026-09-26
A systematic review and meta-analysis of 15 studies (20,635 ureteroscopic procedures) found pooled ureteral perforation incidence of 1.89% and avulsion incidence of 0.32%, with rates roughly 10-fold higher in cohorts restricted to impacted stones.
Why it matters: Provides updated benchmark complication rates for informed consent discussions and quality benchmarking in ureteroscopy.
Global survey finds wide cost variation for single-use ureteroscopes and access sheaths Retrospective · Urolithiasis · 2026-09-26
A 40-country collaboration found the median purchase cost of single-use flexible ureteroscopes was 677 euros (range 310 to 1638) and access sheaths 180 euros, with reuse protocols lowering median per-procedure ureteroscope costs to 425 euros.
Why it matters: Relevant to practices considering cost-containment strategies such as device reuse amid rising single-use endourology expenditure.

BPH and male LUTS news

Network meta-analysis: vibegron reduces OAB symptoms as BPH add-on, no clear edge over mirabegron Meta-analysis · World J Urol · 2026-09-29
A Bayesian network meta-analysis of 18 trials found vibegron and mirabegron both reduced micturition frequency and urgency as add-on therapy in alpha-blocker-treated men with BPH and persistent OAB, but indirect comparisons showed no significant advantage of vibegron over mirabegron.
Why it matters: Confirms beta-3 agonists are a reasonable add-on for persistent storage symptoms in men on alpha-blockers, without evidence to prefer one agent.
Meta-analysis supports HoLEP safety in patients on antithrombotic therapy Meta-analysis · UROsource · 2026-09-28
An updated systematic review and meta-analysis found HoLEP to be a safe option for BPH surgery in patients receiving antithrombotic medications.
Why it matters: Supports continuing or minimally interrupting antithrombotics when performing HoLEP in appropriately selected patients.

Female pelvic medicine and neurourology news

Lead migration after sacral neuromodulation more common with one device brand in single-center study Retrospective · Neurourol Urodyn · 2026-10-01
Among 445 patients undergoing sacral neuromodulation, 7.9% had confirmed lead migration; Axonics devices were associated with higher odds of migration than Medtronic devices, and all cases of large migration occurred with Axonics leads.
Why it matters: Device-specific migration risk may inform counseling and postoperative monitoring protocols for SNM patients.

Reconstruction and trauma news

Institutional experience improves 5-year outcomes for gender-affirming penile prosthesis Retrospective · J Sex Med · 2026-09-28
In a retrospective cohort of 473 patients undergoing first-time gender-affirming inflatable penile prosthesis insertion, cumulative institutional experience, single-cylinder implantation, and use of one device brand were linked to lower risk of subsequent surgery, with peak proficiency identified around case 311.
Why it matters: Highlights a long learning curve for gender-affirming IPP surgery, relevant for centers building or scaling these programs.
Novel laparoscopic technique described for refractory piriformis-related pelvic pain Retrospective · J Endourol · 2026-09-26
A retrospective series of 200 patients across multiple institutions describes a transgluteal laparoscopic piriformis muscle transection technique for chronic pelviperineal pain syndrome, reporting technical feasibility with low morbidity and short hospital stay.
Why it matters: Introduces a minimally invasive surgical option for a difficult-to-treat and underrecognized cause of chronic pelvic pain.
Advances in artificial urinary sphincter technology Interview · Urology Times · 2026-09-14
Andrew Peterson, MD, on electronic sphincter innovations for post-treatment incontinence.
Why it matters: Relevant to survivorship care after prostatectomy and radiation.

Men's health news

Mediterranean diet adherence linked to differences in sperm DNA methylation patterns Retrospective · Andrology · 2026-09-30
A cross-sectional study of 60 healthy men found 42 differentially methylated CpG sites in sperm DNA comparing high versus low adherence to the Mediterranean diet, independent of age, smoking, and BMI.
Why it matters: Adds mechanistic evidence for how diet may influence sperm epigenetics, though clinical significance for fertility remains unclear.
PCF-sponsored consensus proposes cardiovascular risk triage schema for men on ADT/ARPi therapy Review · JCO Oncol Pract · 2026-09-29
A narrative review and clinician-industry consensus proposes a three-tier (high/intermediate/low) point-of-care schema to identify prostate cancer patients on hormone therapy who need cardiovascular referral, based on prior CVD events and risk-factor control.
Why it matters: Offers a practical framework for urologists to flag cardiovascular risk in ADT/ARPi patients before formal validation studies are completed.
Placebo injection response notably high across Peyronie's disease trials Retrospective · Renal & Urology News · 2026-09-28
An analysis of Peyronie's disease clinical trials found substantial improvement in placebo-injected control groups, complicating interpretation of active treatment effect sizes.
Why it matters: High placebo response rates in Peyronie's trials should temper enthusiasm for reported treatment effects and inform trial design.

Pediatric urology news

Temporary vesicostomy cuts early complications after pediatric bladder augmentation Retrospective · Neurourol Urodyn · 2026-10-01
In 168 children undergoing ileocystoplasty with catheterizable stoma, temporary incontinent vesicostomy was associated with markedly lower rates of anastomotic leakage, stoma obstruction, and febrile UTI (2.3% vs 28.6% overall complication rate), without affecting 24-month continence or bladder dynamics.
Why it matters: Offers a technical strategy to reduce early morbidity and emergency readmissions after a common pediatric reconstructive procedure.
Review proposes risk-stratified framework for observation versus treatment of pediatric varicocele Review · Nat Rev Urol · 2026-10-01
This narrative review synthesizes evidence on pediatric varicocele management, noting lack of consensus, and proposes a risk-stratified model using grade, testicular volume asymmetry, and semen/hormonal parameters to guide observation versus early intervention.
Why it matters: Offers a practical framework for a common but controversial pediatric urology decision where high-quality outcome data are limited.
New reference curves define expected residual hydronephrosis after pyeloplasty Retrospective · World J Urol · 2026-09-27
In 566 renal units after pyeloplasty, postoperative APD reference curves were built from units without recurrence. Renal pelvic APD above the 90th centile curve was linked to a much higher reoperation rate (11.7% vs 0.8%).
Why it matters: Offers an objective benchmark to decide which children with residual postoperative dilation need closer follow-up versus reassurance.
Insurance status and timing linked to orchiectomy odds after testicular torsion in NY state Retrospective · J Pediatr Urol · 2026-09-27
Among 4,159 children with testicular torsion in New York State over 15 years, 26% underwent orchiectomy; government or self-pay insurance and presentation timing were associated with higher orchiectomy odds, with effects varying by age group.
Why it matters: Points to potential access or systems-level disparities affecting testicle salvage rates that may warrant institutional review.

Practice and policy news

Southland, NZ urology service warns of collapse amid surgery cancellations News · RNZ · 2026-09-30
Local reporting describes concerns that a regional urology service in Southland, New Zealand could collapse as surgeries are being cancelled, reflecting ongoing workforce and access strain.
Why it matters: Illustrates how urology workforce shortages can threaten service continuity even in developed health systems.
Southland, NZ clinicians again warn urology services are at risk of collapse News · whatsoninvers.nz · 2026-09-30
Local doctors reiterated concerns that the Southland, New Zealand urology service faces collapse amid ongoing surgery cancellations and staffing strain.
Why it matters: Highlights persistent workforce and access pressures facing urology services in some regions.
Report alleges Trump administration delayed release of USPSTF recommendations News · MedPage Today · 2026-09-29
MedPage Today reports the administration suppressed or delayed publication of US Preventive Services Task Force recommendations, raising concerns about screening guidance transparency.
Why it matters: USPSTF recommendations, including on PSA screening, guide payer coverage and practice; delays could affect prostate cancer screening policy.
Urology waiting list backlog persists despite fewer long delays News · European Medical Journal · 2026-09-29
A report finds that while the proportion of very long urology waits has fallen, overall waiting list burden for urology patients remains high.
Why it matters: Highlights ongoing capacity strain in urology services relevant to workforce and access planning.

More urology news

Phase 1-2 trial opens testing REGN21353 alone or with nezastomig in mCRPC Trial opening · ClinicalTrials.gov · 2026-09-30
A new phase 1-2 study will evaluate experimental agent REGN21353, alone or combined with nezastomig (and sarilumab in some participants), in previously treated metastatic castration-resistant prostate cancer. Planned enrollment is 192 patients.
Why it matters: Adds another bispecific/immunotherapy combination trial for heavily pretreated mCRPC patients who may be candidates for trial referral.
Pivotal trial opens for GRPR-targeted PET imaging agent in prostate cancer Trial opening · Urology Times · 2026-09-28
A pivotal clinical trial has launched to evaluate a GRPR-targeted PET imaging agent for prostate cancer, an alternative molecular target to PSMA.
Why it matters: New imaging targets beyond PSMA could expand options for staging and recurrence detection.
Industry and academic GU oncology trials stop early for different reasons Retrospective · Urology · 2026-09-27
Analysis of 1,597 phase II-III genitourinary oncology trials on ClinicalTrials.gov found 27.9% terminated early; academic trials mainly failed from poor accrual while industry trials stopped more often for strategic, regulatory, or interim efficacy/futility reasons.
Why it matters: Highlights structural differences in why GU oncology trials fail, relevant to trial design and site participation decisions.

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