Meta-analysis: elevated neutrophil-to-lymphocyte ratio linked to worse survival in RCC

Meta-analysis · Transl Androl Urol · 2026-11-08. Number 5 in the UrologyWatch Top 5 for November 12, 2026.

An updated meta-analysis of 26 cohort studies (6,041 patients) found elevated neutrophil-to-lymphocyte ratio associated with shorter overall, recurrence-free, and disease-free survival in renal cell carcinoma.

Why it matters: Adds support for NLR as a prognostic marker in RCC, though pooled cohort data cannot establish causality or guide individual treatment decisions.

Source: Transl Androl Urol · PubMed 42997244 · DOI 10.21037/tau-2026-0558

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