CT adds little over pelvic MRI for nodal staging in higher-risk prostate cancer, both poor vs pathology
Retrospective · World J Urol · 2026-11-12. Number 4 in the UrologyWatch Top 5 for November 12, 2026.
In 323 patients with unfavorable intermediate- or high-risk prostate cancer, MRI and CT showed only moderate agreement for nodal staging and both had low sensitivity (≤20%) versus surgical pathology; PSMA PET/CT performed better (AUC 0.86) in a subgroup with molecular imaging.
Why it matters: Raises the question of whether conventional CT adds meaningful nodal staging value when PSMA PET is available.
Limitation: Retrospective single-center cohort; PSMA PET comparison limited to a small subgroup (n=82).
Source: World J Urol · PubMed 43013110 · DOI 10.1007/s00345-026-06877-1
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