Preoperative sarcopenia linked to worse survival after radical cystectomy
Retrospective · Clin Genitourin Cancer · 2026-11-07. Number 5 in the UrologyWatch Top 5 for November 9, 2026.
In a single-center cohort of 320 patients, CT-defined sarcopenia (present in 50%) was independently associated with worse overall survival after radical cystectomy (HR 1.52), though not with major complications or ICU use.
Why it matters: Raises the question of whether CT-based muscle mass assessment could help risk-stratify cystectomy candidates, but is hypothesis generating from a single-center retrospective cohort.
Limitation: Single-center retrospective design; association attenuated with alternative muscle mass cutoffs, suggesting sensitivity to definition.
Source: Clin Genitourin Cancer · PubMed 42995123 · DOI 10.1016/j.clgc.2026.102695
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