Meta-analysis: PAMORAs linked to faster bowel recovery after radical cystectomy
Meta-analysis · Transl Androl Urol · 2026-10-14. Number 4 in the UrologyWatch Top 5 for October 17, 2026.
A systematic review and meta-analysis found that adding peripherally acting mu-opioid receptor antagonists (alvimopan, naloxegol, methylnaltrexone) to enhanced recovery pathways after radical cystectomy was associated with shortened time to first flatus and improved postoperative GI recovery versus enhanced recovery alone, though certainty of evidence varied and data specific to cystectomy remain limited and…
Why it matters: Suggests PAMORAs may help reduce postoperative ileus after cystectomy, but evidence quality is variable and more robust data are needed before routine incorporation into enhanced recovery protocols.
Limitation: Included study designs and certainty of evidence varied; pooled estimates combine heterogeneous trial and observational data.
Source: Transl Androl Urol · PubMed 42866437 · DOI 10.21037/tau-2026-0432
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